Fenbendazole for cancer treatment
Discussion
Was just idly reading about some guy with cancer and he’d tried everything and was resigned to his fate.
Someone mentioned fenbendazole (which is a drug to treat worms and other infestations in animals!) and he tried it and his rumour has reduced.
I’ve googled it and although no real trials have been done it appears the medical world has known about it since 2002.
Mice in a laboratory with implanted cancer cells contracted worms so they gave them a dose of fenbendazole (wow, they must really care!) and they found the rumours shrank or stayed in stasis, or whatever the word is.
https://healthunlocked.com/advanced-prostate-cance...
Anyway. Interesting nonetheless.
Someone mentioned fenbendazole (which is a drug to treat worms and other infestations in animals!) and he tried it and his rumour has reduced.
I’ve googled it and although no real trials have been done it appears the medical world has known about it since 2002.
Mice in a laboratory with implanted cancer cells contracted worms so they gave them a dose of fenbendazole (wow, they must really care!) and they found the rumours shrank or stayed in stasis, or whatever the word is.
https://healthunlocked.com/advanced-prostate-cance...
Anyway. Interesting nonetheless.
It's true, and it works.
I'll explain it in a basic way hopefully anyone reading will understand. If not, I can clarify points.
Cancer, for whatever the underlying cause, is a fault in a cell that causes it to divide and continue to divide. The cell divides over and over again. Usually, but not always, this is due to a fault in the cells DNA. The cell decides to then divide, to try and repair the DNA. Thre's a lot of different enzymes and proteins involved in this process.
A cell can't simply divide, though. It needs orientation, structure, it needs to know which way is up, down, left and right. The cell does this by growing long spindly strands, from one end of the cell to another.
The nucleus, with all the DNA in it, sticks to the spindles and the DNA replicates, the spindles then twang back like elastic bungee cords, pulling all the DNA with it to either end of the cell; cell then divides.
All this involves the role of a protein called Tubulin. The cancer drug vincristine really buggers up tubule formation.
Other cancer drugs affect other parts of the cell division process. Rapidly dividing cells are very susceptible to radiation, which is why radiotherapy works. The faster a cell divides, the more likely it'll be walloped and croak when irradiated. On the contrary, cells which rarely divide don't get affected by radiation as much, most notably insects. That's how cockroaches can survive massive doses of radiation. They don't have much cell division.
Tubulin has a lot of other purposes, too. As the name suggests, it forms tubes. Think of it like copper tubes. You can use the copper tube to stab a football and move it across the garden, in the same way organelles are moved around in a cell. Or it can be used like a straw, to suck stuff through. For example, insects don't have lungs, they have spirioles - a network of pipes and tubes through which air moves.
Or, you can write a message on a piece of paper, roll it up, poke it in the tube and with a puff of air, blow the paper down the tube. In the same way, tubulin can help transmit messages.
In parasitic worms, the tubules aid homeostasis; allowing the worm to eat and breathe.
Fenbendazole binds to tubulin, and causes the tubes to sort of spring open. This upsets the parasitic worm and as they yell 'oh my god' they suddenly detach themselves from the yummy intestinal lining and get pooped out.
Now, apologies if I don't get the next bit spot on, I'm in the pub on my ipad and it lacks google, so gotta go from memory...
The problem with fenbendazole is it doesn't really allow itself to be absorbed easily. Systemic availability and ingested dose is not a linear relationship - you won't get more in the blood stream if you take a higher dose. Chomping on fatty foods, such as KFC will aid absorbtion though.
Higher doses can also have some nasty side effects too, which is why dog wormer doesn't make an ideal cancer drug - but that's what makes cancer drugs so effective. For example, it can trash all the microtubules in the intestinal epithelium, stripping it away; resulting in an effect not too dissimilar to picolax.
That being said, why do we pay £500 for vincristine when £5 of dog wormer works the same way, and produces the same end result?
That, I suspect, is a discussion for another thread. But if you want my opinion, cancer is big business and eventually, the truth about the whole industry will come out.
I'll explain it in a basic way hopefully anyone reading will understand. If not, I can clarify points.
Cancer, for whatever the underlying cause, is a fault in a cell that causes it to divide and continue to divide. The cell divides over and over again. Usually, but not always, this is due to a fault in the cells DNA. The cell decides to then divide, to try and repair the DNA. Thre's a lot of different enzymes and proteins involved in this process.
A cell can't simply divide, though. It needs orientation, structure, it needs to know which way is up, down, left and right. The cell does this by growing long spindly strands, from one end of the cell to another.
The nucleus, with all the DNA in it, sticks to the spindles and the DNA replicates, the spindles then twang back like elastic bungee cords, pulling all the DNA with it to either end of the cell; cell then divides.
All this involves the role of a protein called Tubulin. The cancer drug vincristine really buggers up tubule formation.
Other cancer drugs affect other parts of the cell division process. Rapidly dividing cells are very susceptible to radiation, which is why radiotherapy works. The faster a cell divides, the more likely it'll be walloped and croak when irradiated. On the contrary, cells which rarely divide don't get affected by radiation as much, most notably insects. That's how cockroaches can survive massive doses of radiation. They don't have much cell division.
Tubulin has a lot of other purposes, too. As the name suggests, it forms tubes. Think of it like copper tubes. You can use the copper tube to stab a football and move it across the garden, in the same way organelles are moved around in a cell. Or it can be used like a straw, to suck stuff through. For example, insects don't have lungs, they have spirioles - a network of pipes and tubes through which air moves.
Or, you can write a message on a piece of paper, roll it up, poke it in the tube and with a puff of air, blow the paper down the tube. In the same way, tubulin can help transmit messages.
In parasitic worms, the tubules aid homeostasis; allowing the worm to eat and breathe.
Fenbendazole binds to tubulin, and causes the tubes to sort of spring open. This upsets the parasitic worm and as they yell 'oh my god' they suddenly detach themselves from the yummy intestinal lining and get pooped out.
Now, apologies if I don't get the next bit spot on, I'm in the pub on my ipad and it lacks google, so gotta go from memory...
The problem with fenbendazole is it doesn't really allow itself to be absorbed easily. Systemic availability and ingested dose is not a linear relationship - you won't get more in the blood stream if you take a higher dose. Chomping on fatty foods, such as KFC will aid absorbtion though.
Higher doses can also have some nasty side effects too, which is why dog wormer doesn't make an ideal cancer drug - but that's what makes cancer drugs so effective. For example, it can trash all the microtubules in the intestinal epithelium, stripping it away; resulting in an effect not too dissimilar to picolax.
That being said, why do we pay £500 for vincristine when £5 of dog wormer works the same way, and produces the same end result?
That, I suspect, is a discussion for another thread. But if you want my opinion, cancer is big business and eventually, the truth about the whole industry will come out.
JapanRed said:
Great post Wiccan. Could you clarify your background / how you know this? Just so people can take it in context.
Do you really think there is a cover up on cancer treatment? I can’t believe it personally.
Without knowing about the original issue - I think you can be reasonably certain there is manipulation of treatments by the drug companies. They are billion pound industries and have reps going round seeing doctors pushing their latest "developments", this isn't for patient well being but to maximise profits. Doctors seldom deal with the root causes but instead prefer us all to be on a lifetime of drugs.Do you really think there is a cover up on cancer treatment? I can’t believe it personally.
Without wanting to derail - Marijuana would appear to have significant health properties yet isn't used. Is this because of drug companies lobbying parliament?
Sorry if the above comes across as a tin foil hat but I have zero faith in drug companies or the politicians who set the policies.
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