Immune discovery 'may treat all cancer'

Immune discovery 'may treat all cancer'

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Discussion

Nickgnome

8,277 posts

89 months

Tuesday 21st January 2020
quotequote all
Thales said:
marksx said:
Cue the conspiracy theorists saying 'they' won't let it happen.
It's not a conspiracy. Big pharma is BIG business.
The scale of investment required to produce new medicines is astronomical and I’m sure you are fully conversant of the patent and approval process which results in a relatively short un-competed sales period.

It is big business with significant risk.

I was involved with Glaxo, Stevenage construction. It was a massive investment at the time.

Nickgnome

8,277 posts

89 months

Tuesday 21st January 2020
quotequote all
ash73 said:
Should they cure cancer? Should they offer the cure to everyone? Do we need more old people?

Do people want to live to 150, a third of it with dementia?
Not everyone gets dementia.

Some die well in their 90s with way more grey cells intact than many half their age.


DanL

6,215 posts

265 months

Tuesday 21st January 2020
quotequote all
ash73 said:
Should they cure cancer? Should they offer the cure to everyone? Do we need more old people?

Do people want to live to 150, a third of it with dementia?
You enjoy dying of cancer if you wish - I’ll take a cure if I have the option and need it!

ETA: I’ll live as long as I’m able to - if I can decide that I’ve had enough, that’s fine. Otherwise, living to 1,000 would be great, thanks, assuming there’s a way to keep me active and otherwise together...

marksx

5,052 posts

190 months

Tuesday 21st January 2020
quotequote all
Nickgnome said:
Thales said:
marksx said:
Cue the conspiracy theorists saying 'they' won't let it happen.
It's not a conspiracy. Big pharma is BIG business.
The scale of investment required to produce new medicines is astronomical and I’m sure you are fully conversant of the patent and approval process which results in a relatively short un-competed sales period.

It is big business with significant risk.

I was involved with Glaxo, Stevenage construction. It was a massive investment at the time.
Oh I know, I work in pharma. For one of the companies that swoops in after the patent is up.

DanL

6,215 posts

265 months

Tuesday 21st January 2020
quotequote all
ash73 said:
DanL said:
You enjoy dying of cancer if you wish - I’ll take a cure if I have the option and need it!
Where do you stop, should they cure aging? Where are you going to put everyone?
Answered in my edit above - given the option, I’d never die. As for where you’d put everyone, I’d think that as life spans extend birth rates would fall dramatically. It’s close to equilibrium (or below) in a number of developed countries already.

Nickgnome

8,277 posts

89 months

Tuesday 21st January 2020
quotequote all
ash73 said:
DanL said:
You enjoy dying of cancer if you wish - I’ll take a cure if I have the option and need it!
Where do you stop, should they cure aging? Where are you going to put everyone?
We have no shortage of space. In the UK the actual constructed on bit represents less than 2% of the available land. If you include gardens and parks etc your looking at less than 6%.

We haven’t stopped ageing but surely keeping people as healthy as they can be until they die has to be a good think.

On what basis can you possibly select? Why should it be age? How about worth to society, not just fiscal?

Nickgnome

8,277 posts

89 months

Tuesday 21st January 2020
quotequote all
DanL said:
Answered in my edit above - given the option, I’d never die. As for where you’d put everyone, I’d think that as life spans extend birth rates would fall dramatically. It’s close to equilibrium (or below) in a number of developed countries already.
I’m not sure it’s quite that simple. My Dad had kidney cancer in his mid 50s. They operated promptly and he survived and was very productive and active after. He as very active until the age of 83. When he got Osteoporosis he simply stopped eating. Died at the age of 87.

Murph7355

37,715 posts

256 months

Tuesday 21st January 2020
quotequote all
DanL said:
ash73 said:
DanL said:
You enjoy dying of cancer if you wish - I’ll take a cure if I have the option and need it!
Where do you stop, should they cure aging? Where are you going to put everyone?
Answered in my edit above - given the option, I’d never die. As for where you’d put everyone, I’d think that as life spans extend birth rates would fall dramatically. It’s close to equilibrium (or below) in a number of developed countries already.
Will you pay for it directly? smile

Murph7355

37,715 posts

256 months

Tuesday 21st January 2020
quotequote all
Nickgnome said:
We have no shortage of space. In the UK the actual constructed on bit represents less than 2% of the available land. If you include gardens and parks etc your looking at less than 6%.

We haven’t stopped ageing but surely keeping people as healthy as they can be until they die has to be a good think.

On what basis can you possibly select? Why should it be age? How about worth to society, not just fiscal?
Many things are good things... Until they have to be paid for.

The NHS is the problem it is partly because technology has improved faster than our willingness to fund it and the unintended consequences. In some circumstances it is causing its own issues.

Huge rethinks are needed, and Ash73's question is very relevant - just because we can do something, should we?

This was a large part of a post grad AI course I took in 1993...

DanL

6,215 posts

265 months

Tuesday 21st January 2020
quotequote all
Murph7355 said:
Will you pay for it directly? smile
Depends on the price and what it is. biggrin

Cancer cure? Should be covered by my insurance. Living forever? If I can afford it. If the outcome is effectively to stop / reverse ageing, you’d probably be able to get a loan against future earnings.

If your complaint is that it’ll be too expensive for the NHS - I’m sure this is true. However, what starts out as exclusive and expensive will likely become commoditised and mainstream over time, given sufficient demand...

king arthur

6,566 posts

261 months

Tuesday 21st January 2020
quotequote all
ash73 said:
Should they cure cancer? Should they offer the cure to everyone? Do we need more old people?

Do people want to live to 150, a third of it with dementia?
Cancer is not necessarily an age related disease.

Nickgnome

8,277 posts

89 months

Tuesday 21st January 2020
quotequote all
Murph7355 said:
Many things are good things... Until they have to be paid for.

The NHS is the problem it is partly because technology has improved faster than our willingness to fund it and the unintended consequences. In some circumstances it is causing its own issues.

Huge rethinks are needed, and Ash73's question is very relevant - just because we can do something, should we?

This was a large part of a post grad AI course I took in 1993...
Yes. I think in general yes we should.

As soon as we stop developing in every area the human race will wither away.

Surely, one of our key drivers is betterment, in every sense of the word.

Challenges are not a reason or excuse not to develop.






pavarotti1980

4,898 posts

84 months

Wednesday 22nd January 2020
quotequote all
BevR said:
I thought UCL was still doing quite a few CAR-T trials? I would imagine that as new CAR-T treatments come out there would be a need to more centers to become accredited, assuming they are affordable.

Have any patients been treated with Kymriah in the UK yet? I seem to remember that the number of patients in the US was not as high as Novartis expected.
Yeah more than Yescarta.

there are numerous sites doing trials still but the main sites for processing the cells commerically is US & Germany

BoRED S2upid

19,702 posts

240 months

Wednesday 22nd January 2020
quotequote all
Nickgnome said:
We have no shortage of space. In the UK the actual constructed on bit represents less than 2% of the available land. If you include gardens and parks etc your looking at less than 6%.

We haven’t stopped ageing but surely keeping people as healthy as they can be until they die has to be a good think.

On what basis can you possibly select? Why should it be age? How about worth to society, not just fiscal?
This is true for the UK, nimbies may not like it but we have masses of space in the U.K. just look at how many people China cram into their cities (not that you would want that) but there is plenty of space and even more space to grow food. You only need to take a long train journey to see mile after mile of farmland without crops or animals growing on it.

Something will kill us all in the end it doesn’t have to be cancer.

AJL308

6,390 posts

156 months

Wednesday 22nd January 2020
quotequote all
ash73 said:
Should they cure cancer? Should they offer the cure to everyone? Do we need more old people?

Do people want to live to 150, a third of it with dementia?
I decided years ago that I was going to live until at least 150. Wouldn't want to with dementia though.

Shaoxter

4,079 posts

124 months

Wednesday 22nd January 2020
quotequote all
ash73 said:
DanL said:
You enjoy dying of cancer if you wish - I’ll take a cure if I have the option and need it!
Where do you stop, should they cure aging? Where are you going to put everyone?
This was covered in a Justin Timberlake film... In the future when people could live forever, everyone had a timer and you would die if it reached zero. Time became the main commodity so you could earn it and spend it. Quite an interesting idea I thought, although I don't recall the film itself to be any good.