Discussion
Thevet said:
Ivermectin is not licensed in the UK for dogs, it is licensed in the US where they have heart worm problems, but it is toxic if used above the US dose rate in collies. Why do you need to know when there are plenty of safer treatments available albeit more costly?
Thanks for the words of wisdom, I started the thread because these days many products ( human and animal ) don't do what it says on the tin, some of the claims are just wrong.Obviously Ivermectin for dogs and Ronseal for fences do the job 100% and in contrast Mercedes used to be put together from high quality parts yet nowadays don't
Thevet said:
I've used at the US dose rate, many years ago, think it was 1cc per 50kg, never had a problem, but why bother now when there are so many approved alternatives.
1ml/50Kg is the rate for cattle with Ivomec Injection. No idea if it is the same for Dogs. BUT, as several farmers have found to their cost, Collies seem quite sensitive to ivermectin and it has proved terminal in some cases. I have no idea if other breeds are equally sensitive but i for one would not consider the use of ivermectin on one of my dogs and i use a large amount of it on cattle and always have it in stock.Dose is the same but you try getting a cattle farmer to assess 0.5cc or less for a collie that he has little idea of its weight. It is critical for collies with little safety margin hence no uk licence. I used it quite a few times early in my career for cases of demodex which couldn't be treated any other way, but weight was carefully measured.
It's an old school treatment for mange in dogs but was always off licence (iirc) but far better products now so really no reason to use it now unless all other treatments fail, it was used at one tine to dose foxes when there was a mange outbreak (not sure if that still happens-the tx, not the mange) , can still be used to successfully treat mites in small animals and is licensed for it (xeno drops)
I assume it is still used in large animal veterinary medicine.
I assume it is still used in large animal veterinary medicine.
Thevet said:
You're back!!! 
yes it is widely used in farm practice
wasn't expecting that response but thank you yes it is widely used in farm practice
Not really back just popping in every now and then.
Thought it probably was but I never really worked in large animal practice (though with the size of some dog breeds, some may argue that!) so wasn't really sure.
We were warned about ivermectin from our breeder as we have hearing dogs.
https://www.goddardvetgroup.co.uk/why-shouldnt-my-...
“
So what stops it getting into the brain, if it’s in the dog’s bloodstream?
All mammals, including dogs, have a special membrane surrounding the brain, called the Blood Brain Barrier. It works to prevent nasty chemicals getting into our brains and causing problems with the sensitive nerve cells there.
So there’s something unusual about the Blood Brain Barrier in collies then?
Yes, exactly. There is a particular genetic mutation, called MDR1? (also known as ABCB1, just to confuse people…) that means the barrier doesn’t work properly, and allows certain types of chemical through. One of these types is (you’ve guessed it!) the macrocyclic lactones – including ivermectin.
So all collies have this mutation do they?
No – but lots (perhaps as many as 75%) of them do. And a wide range of other dogs also have high incidence of this mutant gene – in fact, we’d generally advise against the use of ivermectin in any herding-type dog.
“
https://www.goddardvetgroup.co.uk/why-shouldnt-my-...
“
So what stops it getting into the brain, if it’s in the dog’s bloodstream?
All mammals, including dogs, have a special membrane surrounding the brain, called the Blood Brain Barrier. It works to prevent nasty chemicals getting into our brains and causing problems with the sensitive nerve cells there.
So there’s something unusual about the Blood Brain Barrier in collies then?
Yes, exactly. There is a particular genetic mutation, called MDR1? (also known as ABCB1, just to confuse people…) that means the barrier doesn’t work properly, and allows certain types of chemical through. One of these types is (you’ve guessed it!) the macrocyclic lactones – including ivermectin.
So all collies have this mutation do they?
No – but lots (perhaps as many as 75%) of them do. And a wide range of other dogs also have high incidence of this mutant gene – in fact, we’d generally advise against the use of ivermectin in any herding-type dog.
“
Gassing Station | All Creatures Great & Small | Top of Page | What's New | My Stuff