Things you always wanted to know the answer to [Vol. 3]
Discussion
Wiccan of Darkness said:
Long term paracetamol use is just as bad. Taking a daily dose below the "daily maximum" for a week or more will destroy the liver just as effectively. Takes a while for the liver to fully process it, and if serum levels are topped up before the last has been metabolised (half life is about 2-2.5 hours) there's still drug in the serum whern the next dose is taken.
After a week, the metabolites of the paracetamol start to affect the liver, and essential compounds used in the metabolism deplete further, the risk of liver damage increases. Remember, you're not even overdosing.
One of the metabolites is quite reactive, and remains sat in the liver, attached to essential compounds and gradually accumulates further, until the metabolites reach toxic levels. Liver necrosis sets in, and after the 'tipping point' is reached (10 days or so depending on various factors) any further paracetamol taken has nothing to bind to, and rapid liver failure commences.
There are several documented cases where people have died from paracetamol overdoses, when they haven't overdosed, simply taken the 'limit' for 7-10 days and suddenly become seriously unwell.
Care to share a source?After a week, the metabolites of the paracetamol start to affect the liver, and essential compounds used in the metabolism deplete further, the risk of liver damage increases. Remember, you're not even overdosing.
One of the metabolites is quite reactive, and remains sat in the liver, attached to essential compounds and gradually accumulates further, until the metabolites reach toxic levels. Liver necrosis sets in, and after the 'tipping point' is reached (10 days or so depending on various factors) any further paracetamol taken has nothing to bind to, and rapid liver failure commences.
There are several documented cases where people have died from paracetamol overdoses, when they haven't overdosed, simply taken the 'limit' for 7-10 days and suddenly become seriously unwell.
There are a hell of a lot of people on long-term paracetamol. Tens of thousands, I expect. They are not dropping like flies with liver failure on day 10. Or day 30, or at all. It's a very standard part of a lot of long-term pain management plans for people with chronic pain.
MartynVRS said:
How much paracetamol is in two packets? I'm not sure as I always take it within something else like Ibuprofen when I had toothache a few weeks ago, mainly for the anti-inflammatory. I take co-docamol for a bad back (30/500's) and have been on and off for the last few years. They say not to take more than 8 a day which I never do but have taken 8 a day in the past when it's been really bad. The norm is 2 in the morning then 2 in the evening after food and never had any issues.
Nearly all paracetamol is 500mg tabs; for a normal adult male you'll get in to trouble around the 15 tabs a day mark. The maximum 8 a day is half the danger level.The issue about long term use is not the paracetamol itself, but what it binds to in the liver during metabolism and long term use slowly depletes it. If you're on 8 co-codamol a day you should be ok unless you're 6 stone. The bottom line is paracetamol removes this binding agent, and if the binding agent is removed faster than it can be replaced, suddenly you have no binding agent and you're in the poop.
Problems arise with over the counter things like lemsip, which also contain paracetamol and people overdose as they don't take in to consideration the added paracetamol in the various preparations.
I can't give specific advice as I don't know your age, body weight, lifestyle, any other health issues etc but if you're taking paracetamol longer term, even as low as 4000mg a day (8 tablets) then after a week you should see your GP who will do a liver function test, plus prescribe something a little more appropriate.
The upside is even with mild to moderate liver damage, the liver will fully repair itself.
Just be aware if you're on 8 co-codamol a day, either 15/500 or 30/500 then don't take anything else that contains paracetamol. You're already up to the daily maximum. Drop me a PM if you're that concerned.
So I'm just done watching a new MightyCardMods video where they stuff in a 600hp engine into a toyota Cresta with a view to get a '10 second' car. they made a remark that if you own something that can do 10.5 or less you get kicked from the drag strip (that they was at) and not allowed back... why?
RATATTAK said:
Where do pigeons nest ?
Here: https://www.pistonheads.com/gassing/topic.asp?h=0&...(...and http://pigeonsnest.co.uk/stuff/crapstuff/stuart_fo...
)Edited by schmunk on Monday 12th June 21:10
RATATTAK said:
Where do pigeons nest ?
Wood pigeons nest in trees and hedges about 10 feet off the ground. The nests are really just a pile of sticks in a fork in the branches. They like elms around here.Edited by RATATTAK on Monday 12th June 21:15
Feral pigeons like buildings, I think, because they would naturally nest on cliff faces and it's a similar type of environment for them. Again, just a pile of sticks, feather and s
t. Willy Nilly said:
Wood pigeons nest in trees and hedges about 10 feet off the ground. The nests are really just a pile of sticks in a fork in the branches. They like elms around here.
Feral pigeons like buildings, I think, because they would naturally nest on cliff faces and it's a similar type of environment for them. Again, just a pile of sticks, feather and st.
Thanks WN that answers my questionFeral pigeons like buildings, I think, because they would naturally nest on cliff faces and it's a similar type of environment for them. Again, just a pile of sticks, feather and s
t. ambuletz said:
So I'm just done watching a new MightyCardMods video where they stuff in a 600hp engine into a toyota Cresta with a view to get a '10 second' car. they made a remark that if you own something that can do 10.5 or less you get kicked from the drag strip (that they was at) and not allowed back... why?
Just a guess, but the recent Dodge Stupid HP Challenger was also advertised as doing high 9's quarter mile stock and being "banned" for being "too fast".What it actually seems to mean is that when you hit a certain level of performance, you enter another class of car and thus require extra safety equipment, cage etc. It also means that you yourself require a competition licence.
Presumably this is to stop garden shed specials made from glue and 1000HP driven by dreamers.
http://jalopnik.com/heres-why-the-dodge-challenger...
glazbagun said:
In the 20th century they used satellites to go-over their original measurement of the Meridian and found they were out by about 0.23mm per metre which is pretty cool given the tools they had.
Even more amazing is that Copernicus in the 14/1500s calculated the trajectory of planets and stars with only a very large piece of paper and a pencil and got it pretty well right. Wiccan of Darkness said:
Nearly all paracetamol is 500mg tabs; for a normal adult male you'll get in to trouble around the 15 tabs a day mark. The maximum 8 a day is half the danger level.
The issue about long term use is not the paracetamol itself, but what it binds to in the liver during metabolism and long term use slowly depletes it. If you're on 8 co-codamol a day you should be ok unless you're 6 stone. The bottom line is paracetamol removes this binding agent, and if the binding agent is removed faster than it can be replaced, suddenly you have no binding agent and you're in the poop.
Problems arise with over the counter things like lemsip, which also contain paracetamol and people overdose as they don't take in to consideration the added paracetamol in the various preparations.
I can't give specific advice as I don't know your age, body weight, lifestyle, any other health issues etc but if you're taking paracetamol longer term, even as low as 4000mg a day (8 tablets) then after a week you should see your GP who will do a liver function test, plus prescribe something a little more appropriate.
The upside is even with mild to moderate liver damage, the liver will fully repair itself.
Just be aware if you're on 8 co-codamol a day, either 15/500 or 30/500 then don't take anything else that contains paracetamol. You're already up to the daily maximum. Drop me a PM if you're that concerned.
What happened to that "safe" paracetamol that was out a few years back? I think it contained N-acetylcysteine as well as the paracetamol, which is what they give you as soon as they find out you've taken an overdose in the hope of saving you (I think). Dont't remember when or why it left the shelves, but it was regarded as a huge step forward when it first went on the market?The issue about long term use is not the paracetamol itself, but what it binds to in the liver during metabolism and long term use slowly depletes it. If you're on 8 co-codamol a day you should be ok unless you're 6 stone. The bottom line is paracetamol removes this binding agent, and if the binding agent is removed faster than it can be replaced, suddenly you have no binding agent and you're in the poop.
Problems arise with over the counter things like lemsip, which also contain paracetamol and people overdose as they don't take in to consideration the added paracetamol in the various preparations.
I can't give specific advice as I don't know your age, body weight, lifestyle, any other health issues etc but if you're taking paracetamol longer term, even as low as 4000mg a day (8 tablets) then after a week you should see your GP who will do a liver function test, plus prescribe something a little more appropriate.
The upside is even with mild to moderate liver damage, the liver will fully repair itself.
Just be aware if you're on 8 co-codamol a day, either 15/500 or 30/500 then don't take anything else that contains paracetamol. You're already up to the daily maximum. Drop me a PM if you're that concerned.
vonuber said:
northwest monkey said:
Why is petrol & diesel priced at 114.9p per litre & not just 115p ?
You perceive it as cheaper. Hence things being 99p etcks! Exactly like Vonuber said.guindilias said:
What happened to that "safe" paracetamol that was out a few years back? I think it contained N-acetylcysteine as well as the paracetamol, which is what they give you as soon as they find out you've taken an overdose in the hope of saving you (I think). Dont't remember when or why it left the shelves, but it was regarded as a huge step forward when it first went on the market?
Paradote, apparently - taken off the market a while back due to expense and possible side-effects from the antidote it was mixed with.http://www.doctoralia.co.uk/medication/paradote-96...
Dr Jekyll said:
Are any carnivorous animals (other than humans) capable of recognizing their prey's footprints and following them?
Not to answer your question, but wouldn't most animals have evolved to track scent (which is guaranteed to be fairly fresh, thus reliable) rather than footprints which could be days* old?* or, errr, 19,000 years: http://news.nationalgeographic.com/2016/10/ancient...
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