Vaccine side effects

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Discussion

smn159

12,925 posts

219 months

Wednesday 24th March 2021
quotequote all
ElectricSoup said:
smn159 said:
mybrainhurts said:
If only they'd completed those phase 4 trials before rollout, eh?

hehe
Drugs do not have to go through Phase 4 before being approved for use. Phase 3 is the final hurdle befoer approval. Phase 4 is then a data collection exercise, which helps the drug company refine dosage, and find any other side-effects, and spot if the drug is useful against any other conditions. Phase 4 trials are opened to a very large patient population, because they are not about safety, as safety is proven at Phase 3.

I am a former Programme Manager in Clinical Trial data capture. Stop spreading misinformation.

I had my AZ yesterday and I'm sitting here feeling nauseous, got a headache, aches and pains, feeling lethargic, sore arm. All the greatest hits. Like a medium grade hangover truth betold. Still glad I had it.
You are correct and it was aimed at the poster above, who was complaining previously about unknown long term side effects because the phase 4 trials hadn't been completed before rollout.

When several posters pointed out the gap in his understanding he didn't resurface on the matter until now...

ElectricSoup

8,202 posts

153 months

Wednesday 24th March 2021
quotequote all
smn159 said:
ElectricSoup said:
smn159 said:
mybrainhurts said:
If only they'd completed those phase 4 trials before rollout, eh?

hehe
Drugs do not have to go through Phase 4 before being approved for use. Phase 3 is the final hurdle befoer approval. Phase 4 is then a data collection exercise, which helps the drug company refine dosage, and find any other side-effects, and spot if the drug is useful against any other conditions. Phase 4 trials are opened to a very large patient population, because they are not about safety, as safety is proven at Phase 3.

I am a former Programme Manager in Clinical Trial data capture. Stop spreading misinformation.

I had my AZ yesterday and I'm sitting here feeling nauseous, got a headache, aches and pains, feeling lethargic, sore arm. All the greatest hits. Like a medium grade hangover truth betold. Still glad I had it.
You are correct and it was aimed at the poster above, who was complaining previously about unknown long term side effects because the phase 4 trials hadn't been completed before rollout.

When several posters pointed out the gap in his understanding he didn't resurface on the matter until now...
Ah right then I owe you an apology.

Oilchange

8,534 posts

262 months

Wednesday 24th March 2021
quotequote all
ElectricSoup said:
Drugs do not have to go through Phase 4 before being approved for use. Phase 3 is the final hurdle befoer approval. Phase 4 is then a data collection exercise, which helps the drug company refine dosage, and find any other side-effects, and spot if the drug is useful against any other conditions. Phase 4 trials are opened to a very large patient population, because they are not about safety, as safety is proven at Phase 3.

I am a former Programme Manager in Clinical Trial data capture. Stop spreading misinformation.

I had my AZ yesterday and I'm sitting here feeling nauseous, got a headache, aches and pains, feeling lethargic, sore arm. All the greatest hits. Like a medium grade hangover truth betold. Still glad I had it.
Glad you got the jab and hope you feel better soon.
Those symptoms would likely be far worse if you got Covid proper speaking from experience, my God, the headache!

Zad

12,721 posts

238 months

Thursday 25th March 2021
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I got a phone call inviting me for my vaccination on Friday morning, booked in for 4pm on Saturday. I wasn't expecting it for a few weeks at least! They did offer 9am, but I'm never at my best by 9am on a weekend, let alone in lockdown. Turned up 20 mins early, fully expecting to be told to come back later. There was a queue of 2 and I was ushered straight in. I think it took 10 minutes at the outside, and was out before I was due in. All the vaccination stations were working, but there was minimal queueing. I don't think I've ever experienced anything as efficient, yet never felt rushed. After a year of having to deal with a nightmare, the staff could have been forgiven for being slightly off-hand and eager just to crank through the massed public, but they just weren't. I'm sure that if I had had questions or felt apprehensive, then they would have had time for me. They must go through hundreds of people a day but it felt like personal service. Amazing.

Yes I felt the needle go in (OAZ, never been particularly bothered by injections) but it didn't hurt, it just felt bruised and a bit stiff a few minutes later. It did ache for a couple of days, and still feels slightly sore. I did feel slightly odd for a day or so - no idea if that was psychosomatic or actual - and more tired than usual for 3 nights, with a slight temperature. Like I was shrugging off a cold. Just vaguely meh. Had a couple of vaguely weird dreams, but they seem par for the course with lockdown. If anything, my body's response is reassuring me that it is building defences. Kinda the opposite to the placebo effect. The aching arm feels a bit like a badge of honour.


coetzeeh

2,666 posts

238 months

Thursday 25th March 2021
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coetzeeh said:
OAZ - yesterday am. No side effects to report.
Week after my jab and no side effects - feel 100%.

anonymous-user

56 months

Thursday 25th March 2021
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TTmonkey said:
David_M said:
I had mine at the weekend (OAZ) and had essentially no side-effects (I have not had Covid).

Two colleagues who have had Covid also had it at the weekend and have both been completely wiped out - quote "I feel as bad as I did when I had it" (from someone who was bed-ridden for a week, and is not a malingerer).
That’s so weird, the opposite of what you’d guess, isn’t it?
Sorry if I’m missing the point but isn’t all the talk that people who’ve had covid (perhaps unknowingly) get worse side effects from the AZ vaccine?

That’s what my GP and another consultant said to my wife after she had pretty bad side effects anyway.

I assumed it was due to the body remembering the virus (from when you had it) and then makes an active response to it when you get vaccinated.

anonymous-user

56 months

Thursday 25th March 2021
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I was extremely fatigued yesterday, the day after my jab, but happily back to normal today.

Funk

26,383 posts

211 months

Thursday 25th March 2021
quotequote all
garyhun said:
I was extremely fatigued yesterday, the day after my jab, but happily back to normal today.
Good stuff.

How's your new 5G reception...?


hehe

Castrol for a knave

4,870 posts

93 months

Thursday 25th March 2021
quotequote all
Roman Rhodes said:
popeyewhite said:
Oilchange said:
A to Z was a road map. Made of paper.
Back when we had a demand for them, maybe you're just use to satnavs?
Ah, very good. Certainly fell for that one. Not quite of my time but I've heard of the AZ.. in the dim and distant past.
The dim and distant past? How very dare you!

True story: the original A-Z street map was created by a woman. (Checks over shoulder) Amazing anyone got anywhere!
In the time before Sat Nav, I used to do lots of estate valuation work for the pub companies and breweries.

I'd have a dozen pubs a day to visit in some random town, so I'd find a garage, buy an A to Z, and if it was really stsville, Nowhereland, one of those little folding black and white maps because we were off the map (almost).

Life was so much simpler. My little 306 pov spec diesel, Jackie Brambles on the radio, full suit and tie in 30 degree heat and endless flat roofed pubs around Cumbernauld or wherever..

Badda

2,724 posts

84 months

Thursday 25th March 2021
quotequote all
Just had 2nd Pfizer jab. Sore arm so far. The first one was nohting more than arm pain for a few days.

ElectricSoup

8,202 posts

153 months

Thursday 25th March 2021
quotequote all
Castrol for a knave said:
Roman Rhodes said:
popeyewhite said:
Oilchange said:
A to Z was a road map. Made of paper.
Back when we had a demand for them, maybe you're just use to satnavs?
Ah, very good. Certainly fell for that one. Not quite of my time but I've heard of the AZ.. in the dim and distant past.
The dim and distant past? How very dare you!

True story: the original A-Z street map was created by a woman. (Checks over shoulder) Amazing anyone got anywhere!
In the time before Sat Nav, I used to do lots of estate valuation work for the pub companies and breweries.

I'd have a dozen pubs a day to visit in some random town, so I'd find a garage, buy an A to Z, and if it was really stsville, Nowhereland, one of those little folding black and white maps because we were off the map (almost).

Life was so much simpler. My little 306 pov spec diesel, Jackie Brambles on the radio, full suit and tie in 30 degree heat and endless flat roofed pubs around Cumbernauld or wherever..
Which Cumbernauld is this where it's 30 degrees, is there one in Queensland? Or do you mean Farenheit?

hehe

mudster

786 posts

246 months

Thursday 25th March 2021
quotequote all
Not read every post, but most suggest that 12 hours of flu symptoms are the norm commencing 10 hours or so after the jab.

My experience has been slightly different although still within the boundary of symptoms stated on the NHS website (up to 10 days of flu symptoms). As far as I know, I haven't previously had Covid.

• Had the AZ jab at 6pm on Monday
• Tuesday daytime felt tired and achey but nothing that bad. Injection site felt a bit sore.
• Tuesday evening I had the start of shivering, headache, and a temperature of 40-41°C and this lasted 36 hours. Felt pretty ropey and got almost no sleep over 2 nights.
• Had a couple of hours of sweating on Thursday morning which I guess may be the body trying to lower the temperature (after raising it to fight the 'infection') then felt considerably better almost straight away.
• Thursday afternoon now and I just feel really tired which is no great surprise

So not every AZ injection follows exactly the same time frame and symptoms.

I would also advise drinking lots of water as I was really surprised how dehydrated I became.





anonymous-user

56 months

Thursday 25th March 2021
quotequote all
Funk said:
garyhun said:
I was extremely fatigued yesterday, the day after my jab, but happily back to normal today.
Good stuff.

How's your new 5G reception...?


hehe
Interestingly, I can now receive text messages without a phone and they are read to me via a little voice in my head!

scratchchin

J4CKO

41,853 posts

202 months

Thursday 25th March 2021
quotequote all
Has the AZ jab at 10:20 this morning, was ok all day, then about 9pm started shaking quite badly for about 30 mins which seems to have stopped, bit of a sore neck, feel a bit hot in the face.


anonymous-user

56 months

Thursday 25th March 2021
quotequote all
J4CKO said:
Has the AZ jab at 10:20 this morning, was ok all day, then about 9pm started shaking quite badly for about 30 mins which seems to have stopped, bit of a sore neck, feel a bit hot in the face.
Paracetamol and bed might be a good plan.

rider73

3,143 posts

79 months

Friday 26th March 2021
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7 days in for me - started with flu like symptoms again, no headache but sinus/sneezing and feeling a little dizzy and drained again.............!

Lotobear

6,629 posts

130 months

Friday 26th March 2021
quotequote all
I had the AZ vaccine at 8:50am Wednesday morning, felt a little odd by lunchtime and worked through but by evening I felt bloody awful - stomach cramps, feeling sick, incessant flatulence, aches and shooting pains, thudding headache, cold then sweats then repeat. Could not get warm and so went to bed with paracetamol and woke around 1:00am then could not sleep or stay warm for rest of night.

I spent yesterday in bed and started to feel okay by early evening. I'm fine today but the jab site has come up sore and swollen whilst it was previously okay - however I can cope with that!

However I have to say it was bloody unpleasant and if it's this every year or perhaps even twice a year I will think very carefully about having it again and may be prepared to just take my chances with Covid.

In contrast my wife had the jab a few months ago (Pfizer) and had zero reaction.

dr_gn

16,201 posts

186 months

Friday 26th March 2021
quotequote all
Lotobear said:
I had the AZ vaccine at 8:50am Wednesday morning, felt a little odd by lunchtime and worked through but by evening I felt bloody awful - stomach cramps, feeling sick, incessant flatulence, aches and shooting pains, thudding headache, cold then sweats then repeat. Could not get warm and so went to bed with paracetamol and woke around 1:00am then could not sleep or stay warm for rest of night.

I spent yesterday in bed and started to feel okay by early evening. I'm fine today but the jab site has come up sore and swollen whilst it was previously okay - however I can cope with that!

However I have to say it was bloody unpleasant and if it's this every year or perhaps even twice a year I will think very carefully about having it again and may be prepared to just take my chances with Covid.

In contrast my wife had the jab a few months ago (Pfizer) and had zero reaction.
So a couple of days with predictable and manageable flu-like symptoms vs. the real possibility of death, and you'd seriously choose the latter?

J4CKO

41,853 posts

202 months

Friday 26th March 2021
quotequote all
jsf said:
J4CKO said:
Has the AZ jab at 10:20 this morning, was ok all day, then about 9pm started shaking quite badly for about 30 mins which seems to have stopped, bit of a sore neck, feel a bit hot in the face.
Paracetamol and bed might be a good plan.
Yeah, indeed it was !

Was in the middle of our weekly Zoom quiz, so saw that through with a couple of Paracetamol and went to bed.

Wife did her usual "Pathetic man" thing as she had zero side effects, she forgets when she is ill she goes to bed and is far more pathetic than I ever am.

Feel mostly ok today.


Ashfordian

2,083 posts

91 months

Friday 26th March 2021
quotequote all
dr_gn said:
Lotobear said:
I had the AZ vaccine at 8:50am Wednesday morning, felt a little odd by lunchtime and worked through but by evening I felt bloody awful - stomach cramps, feeling sick, incessant flatulence, aches and shooting pains, thudding headache, cold then sweats then repeat. Could not get warm and so went to bed with paracetamol and woke around 1:00am then could not sleep or stay warm for rest of night.

I spent yesterday in bed and started to feel okay by early evening. I'm fine today but the jab site has come up sore and swollen whilst it was previously okay - however I can cope with that!

However I have to say it was bloody unpleasant and if it's this every year or perhaps even twice a year I will think very carefully about having it again and may be prepared to just take my chances with Covid.

In contrast my wife had the jab a few months ago (Pfizer) and had zero reaction.
So a couple of days with predictable and manageable flu-like symptoms vs. the real possibility of death, and you'd seriously choose the latter?
I'm not sure your post is hysterical enough...